Tropical sprue (TS) is a syndrome characterized by acute or chronic diarrhea, weight loss, and malabsorption of nutrients. It occurs in residents. Tropical Sprue; Kwashiorkor. Sprue, both tropical and nontropical, has been a subject of great interest to the medical community ever Sp: Esprue tropical. Tropical sprue is a chronic diarrheal disease, possibly of infectious origin, that involves the small intestine and is characterized by.

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Baker and Klipstein 78 suggested that the diagnosis of tropical sprue should be made only when there is malabsorption of two or more unrelated nutrient groups eg, fat and carbohydrateand after other known causes of malabsorption have been excluded.

Tropical sprue: revisiting an underrecognized disease.

Infect Dis Clin North Am ; Why It Happens and How to Prevent It Since the introduction of the first birth control pill inwomen have come to rely on the pill as an effective way to prevent pregnancy.

Pediatr Infect Dis J 23 — The prognosis for tropical sprue may be excellent after treatment. Eur J Gastroenterol Hepatol 13 — Hawes,pp. Gut 32 — This is identified by quick response to treatment with tetracycline or other antibiotics.

HLA and tropical sprue. Gut 23 — Pathophysiology Nutrient malabsorption in tropical sprue arises from involvement of both the proximal and distal small intestine. Total villous atrophy, espfue reported in coeliac sprue, is rare in tropical sprue. Regarding the definition of tropical sprue. Ultrastructural studies show degenerating cells in the crypts of the small intestine, suggesting stem cell damage.

The disease progresses over variable periods of time to the development of lymphoplasmacytic and immunoblastic lymphoma. Indian J Gastroenterol 23 94— These include I belliC parvum and microsporidia. Am J Med 89 — But in the right hands, food -healthy food – becomes an art form.


Tropical malabsorption

These may comprise using only bottled water for drinking, brushing teeth, and washing food, and avoiding fruits washed with tap water or consuming only peeled fruits, such as bananas and oranges. The need for prolonged residence in the tropics and the response to antibiotics suggested that persistent intestinal infection was responsible. Clinical manifestations A typical patient with tropical sprue is an adult who presents with chronic diarrhoea, glossitis, bloating, prominent bowel sounds and weight loss.

In the process, it has become an extremely significant disease because it is a classical example of a malabsorptive process, and has shed considerable light on intestinal physiology and on other malabsorption syndromes. Common variable immunodeficiency occurs sporadically in residents of the tropics, and may present primarily as a malabsorption syndrome.

Persistent diarrhea in the returned traveler. Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus. Protozoal infections cause malabsorption in immunocompetent hosts, but do esprye more commonly in the setting of immune deficiency.

Am J Trop Med Hyg 10 tropicall Tropical sprue is caused by inflammation of your intestines.

The ileal mucosa displayed more severe villous blunting with higher Marsh stages than in the corresponding duodenum from 5 patients. To help fight against this, she clarifies…. Water and electrolyte absorption by the colon in tropical sprue.

Seasonal gastroenteritis and malabsorption at an Esrue military base in the Philippines: Digestive disease as a national problem.

Tropical sprue – Wikipedia

A description in the ancient Indian medical treatise, Charaka samhitaof an illness characterised by chronic diarrhoea and weight loss and attributed to failure of the digestive system 1 suggests that the malabsorption syndrome was clinically recognised in the trppical two millennia ago. Typically, three faecal samples should be obtained for microscopy, and examined as wet smears after concentration eslrue and with special stains such as safranine methylene blue or modified AFB stains for the protozoan parasites.


Terminal ileal resections can lead to vitamin B 12 deficiencies and bile salt malabsorption, whereas ileocaecal valve resections result in bacterial overgrowth causing malabsorption. J Clin Gastroenterol 39 — Bacterial contamination of the small bowel was described in returning expatriates who developed tropical sprue, 89 as well as in the indigenous population from several regions with endemic eslrue sprue.

A review of laboratory tests of intestinal absorption in the tropics.

Tropical sprue

Tropkcal of fat, vitamin B 12 and xylose, as well as increased mucosal permeability, has been noted in a large number of healthy residents of the tropics. The most common complications of tropical sprue are vitamin and mineral deficiencies. Tropical sprue in expatriates from the tropics living in the continental United States. Nutritional deficiencies and a marked weight loss are documented.

Incidence of IPSID is reducing in areas where it was previously prevalent, probably owing to improving hygiene. There was a mild intraepithelial lymphocytosis and eosinophil infiltrate in the colonic mucosa of half of the cases.

How Is Tropical Sprue Treated? The illness usually starts with an attack of acute diarrhoea, fever and malaise following which, after a variable period, the patient settles into the chronic phase of diarrhoea, steatorrhoea, weight lossanorexiamalaise, and nutritional deficiencies.

Aetiology The aetiology of tropical sprue remains unknown. The condition can lead to growth failure and esprje with bone maturation in children. J Infect Dis — Open in a separate window.